Anti-CD117 (c-KIT), Mouse -BIOTIN Antibody

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Anti-CD117 (c-KIT), Mouse -BIOTIN Antibody
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Cat.No.: Y107332
Quantity: 500 μg
Price: $1,175.00
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Email: [email protected]
Phone: 604-247-2416 (Local), 1-866-757-2414 (Toll free)
Fax: 604-247-2414
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Data Sheet
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Antibody Type primary antibody
Description Rat monoclonal [2B8] to c-Kit (Biotin). c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
Immunogen Mouse CD117/c-Kit
Species Reactivity mouse
Raised In rat
Clonality Conjugated Monoclonal Antibody
Isotype Rat IgG?bκ
Purity Affinity purified
Formulation Liquid
Storage This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Caution Anti-CD117 (c-KIT), Mouse -BIOTIN Antibody is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
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