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Recombinant Human 4-1BB Receptor (TNFRSF9)

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Product Source Size Cat. No. Price
Recombinant Human 4-1BB Receptor (TNFRSF9) CHO cells200 µg Z101425 $680.00
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Data Sheet
Print Version
Alternative Names Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CD_antigen=CD137, CD137, ILA
Recombinant Human 4-1BB (TNFRSF9)
Description 4-1BB Receptor (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated natural killer cells. The binding of 4-1BB to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a costimulatory signal to resting T cells leading to high level IL-2 production independently of CD28 signaling.
Gene Symbol TNFRSF9
Gene ID 3604
Accession No. Q07011
Source CHO cells
Appearance Lyophilized Powder
Molecular Weight 65.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity The activity was tested by the ability of immobilized recombinant mouse 4-1BBL to bind human 4-1BB with a linear range of 10-500 ng/mL.
Formulation Recombinant Human CD137 is lyophilized from 0.2 μm filtered PBS solution, pH7.2.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage Recombinant Human CD137 can be stored in working aliquots at 2° - 8°C for one month, or at -20°C to -70°C for twelve months. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Product Documents
Product References
FAQs
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How are endotoxin levels measured?
1. For estimating the endotoxin levels; we use the LAL (Limulus Amebocyte Lysate) method: The lysate from horseshoe crab amebocytes clots in the presence of very low endotoxin. This reaction is the basis of the Limulus amebocyte lysate (LAL) assay which was approved by the FDA in 1970.

· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).

· For recombinant proteins: EU is reported per microgram of protein.

· One EU = 0.1-0.2 ng endotoxin/µg of protein.

· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.
With regard to the BSA levels in some Growth Factors and Cytokines, can you please provide an explanation as to why they are so high?
The amount of BSA, as part of the formulation of a protein, can vary considerably depending on how much BSA was deemed optimum/necessary for protein stability in combination with /in-lieu of - other possible additives. The aforementioned formulations are somewhat analogous to the “carrier” versions of many formulations from “R and D systems” that have as high as 50 µg of BSA per µg of the recombinant protein product. If, needed or desired, abm scientists can substitute BSA for other stabilizing additives for most formulations.
Are your Escherichia coli sourced growth factors: 1) Human derived materials free? 2) Recombinant proteins free?
Yes, all of abm's growth factors made in Escherichia coli using recombinant technology contain no human derived-products or other recombinant proteins. In the rare cases of BSA presence, this will be mentioned in the product's formulation.