Search Growth Factors & Cytokines By Gene Symbol
Recombinant Human AREG
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|Alternative Names||AR, Colorectum cell-derived growth factor, CRDGF
Recombinant Human Amphiregulin (AREG)
|Description||Amphiregulin is a trans-membrane protein whose protease mediated digestion of the extracellular domain enables release of mature AR. Amphiregulin works to stimulate the proliferation of some animal keratinocyles, epithelial cells and fibroblasts. It has been shown that the mRNA expression of amphiregulin can be detected in numerous carcinoma cell lines and the epithelial cells of various human tissues, including colon, stomach, breast, ovary and kidney.|
|Molecular Weight||11.5 kDa|
|Endotoxin Level||<1.0 EU/μg of recombinant protein as determined by the LAL method.|
|Purity||>95% as determined by SDS-PAGE|
|Bioactivity||Measured in a cell proliferation assay using mouse embryonic fibroblast 3T3 cells. The ED(50) for this effect is <0.5 ng/mL.|
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin|
|Storage||The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.|
|Usage||For research use only. Not for diagnostic or therapeutic use.|
· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).
· For recombinant proteins: EU is reported per microgram of protein.
· One EU = 0.1-0.2 ng endotoxin/µg of protein.
· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.