Search Growth Factors & Cytokines By Gene Symbol
Recombinant Human B-cell Maturation Protein (TNFRSF17)
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|Alternative Names||Tumor necrosis factor receptor superfamily member 17, TNFRSF17, B cell maturation antigen, BCM, BCMA, CD269|
|Description||BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes.The N-terminal part of both mouse and human proteins contains a conserved six-cysteine motif. BLyS binds to three receptors of the TNF receptor family (B cell maturation antigen BCMA, TACI, and BAFF-R), all of which are expressed by mature B cells.|
|Molecular Weight||6.0 kDa|
|Endotoxin Level||<1.0 EU/μg of recombinant protein as determined by the LAL method|
|Purity||>95% as determined by SDS-PAGE|
|Bioactivity||The ED(50) was determined by the dose-dependent proliferation of KMS15 cells and was found to be <0.05ng/mL.|
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS|
|Reconstitution||A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.|
|Storage||The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.|
|Usage||For research use only. Not for diagnostic or therapeutic use.|
· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).
· For recombinant proteins: EU is reported per microgram of protein.
· One EU = 0.1-0.2 ng endotoxin/µg of protein.
· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.