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Recombinant Human CXCL16

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Product Source Size Cat. No. Price
Recombinant Human CXCL16 E. coli25 µg Z102385 $190.00
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Data Sheet
Print Version
Alternative Names Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, transmembrane chemokine CXCL16
Description Chemokine (CXC motif) ligand 16, is a small cytokine belonging to the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 is composed of its typical CXC chemokine domain, a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail which allow CXCL16 to act as a cell surface bound molecule as well as a soluble chemokine. Human CXCL16 shares 70% amino acid sequence similarity with the mouse and CXCL16 expression is induced by IFN-γ and TNF-α. CXCL16 is produced by dendritic cells in lymphoid organs, and by red pulp spleen cells. The expression of CXCL16 may attract lymphocytes during inflammation and assist some immune responses.
Gene Symbol CXCL16
Gene ID 58191
Accession No. Q9H2A7
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 10.4 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Gel Image Click To Enlarge
Bioactivity The ED50 is 2.5-12 ng/mL as determined by its ability to chemoattract activated lymphocytes (at a concentration of 100.0 ng/mL)
Formulation Lyophilized from a 0.2 µm filtered solution in PBS
Reconstitution Reconstitute in sterile PBS at 25µg/mL (containing at least 0.1% human or bovine serum albumin)
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Product Documents
Product References
FAQs
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How are endotoxin levels measured?
1. For estimating the endotoxin levels; we use the LAL (Limulus Amebocyte Lysate) method: The lysate from horseshoe crab amebocytes clots in the presence of very low endotoxin. This reaction is the basis of the Limulus amebocyte lysate (LAL) assay which was approved by the FDA in 1970.

· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).

· For recombinant proteins: EU is reported per microgram of protein.

· One EU = 0.1-0.2 ng endotoxin/µg of protein.

· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.
With regard to the BSA levels in some Growth Factors and Cytokines, can you please provide an explanation as to why they are so high?
The amount of BSA, as part of the formulation of a protein, can vary considerably depending on how much BSA was deemed optimum/necessary for protein stability in combination with /in-lieu of - other possible additives. The aforementioned formulations are somewhat analogous to the “carrier” versions of many formulations from “R and D systems” that have as high as 50 µg of BSA per µg of the recombinant protein product. If, needed or desired, abm scientists can substitute BSA for other stabilizing additives for most formulations.
Are your Escherichia coli sourced growth factors: 1) Human derived materials free? 2) Recombinant proteins free?
Yes, all of abm's growth factors made in Escherichia coli using recombinant technology contain no human derived-products or other recombinant proteins. In the rare cases of BSA presence, this will be mentioned in the product's formulation.