Search Growth Factors & Cytokines By Gene Symbol
Recombinant Human IL37 (IL1F7)
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|Alternative Names||IL-37, IL-23, FIL1 zeta, IL-1X, Interleukin-1 family member 7, IL-1F7, Interleukin-1 homolog 4, IL-1H, IL-1H4, Interleukin-1 zeta, IL-1 zeta, Interleukin-1-related protein, IL-1RP1
Recombinant Human Interleukin-37/Interleukin-23 (IL37/IL23)
|Description||Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Out of the five isoforms for IL-37 (a-e), this product represents isoform B that is expressed in testis, colon, placenta, lung and lymph node similar to isoform A and C but is the only one found in kidneys.|
|Molecular Weight||19.5 kDa|
|Endotoxin Level||<1.0 EU/μg of recombinant protein as determined by the LAL method.|
|Purity||>95% as determined by SDS-PAGE|
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS and DTT|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS|
|Storage||The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.|
|Usage||For research use only. Not for diagnostic or therapeutic use.|
· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).
· For recombinant proteins: EU is reported per microgram of protein.
· One EU = 0.1-0.2 ng endotoxin/µg of protein.
· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.