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Recombinant Human Neuritin

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Product Source Size Cat. No. Price
Recombinant Human Neuritin E. coli20 µg Z102185 $130.00
1.0 mg Z102189 $2,700.00
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Data Sheet
Print Version
Alternative Names NRN1, CPG15, NRN
Description Neuritin is known to play an important role in promoting neuronal survival, differentiation, function, and repair. The expression of Neuritin can be induced in response to neural activity and neurotrophins. NRN1 promotes neurite outgrowth and arborization, especially branching of neuritic processes in primary hippocampal and cortical cells, suggesting its role in promoting neuritogenesis. Overexpression of NRN1 may be associated with astrocytoma progression. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8 kDa polypeptide monomers.
Gene Symbol NRN1
Gene ID 51299
Accession No. Q9NPD7
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 10.4 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity N.A.
Formulation N.A.
Reconstitution N.A.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Product Documents
Product References
FAQs
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How are endotoxin levels measured?
1. For estimating the endotoxin levels; we use the LAL (Limulus Amebocyte Lysate) method: The lysate from horseshoe crab amebocytes clots in the presence of very low endotoxin. This reaction is the basis of the Limulus amebocyte lysate (LAL) assay which was approved by the FDA in 1970.

· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).

· For recombinant proteins: EU is reported per microgram of protein.

· One EU = 0.1-0.2 ng endotoxin/µg of protein.

· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.
With regard to the BSA levels in some Growth Factors and Cytokines, can you please provide an explanation as to why they are so high?
The amount of BSA, as part of the formulation of a protein, can vary considerably depending on how much BSA was deemed optimum/necessary for protein stability in combination with /in-lieu of - other possible additives. The aforementioned formulations are somewhat analogous to the “carrier” versions of many formulations from “R and D systems” that have as high as 50 µg of BSA per µg of the recombinant protein product. If, needed or desired, abm scientists can substitute BSA for other stabilizing additives for most formulations.
Are your Escherichia coli sourced growth factors: 1) Human derived materials free? 2) Recombinant proteins free?
Yes, all of abm's growth factors made in Escherichia coli using recombinant technology contain no human derived-products or other recombinant proteins. In the rare cases of BSA presence, this will be mentioned in the product's formulation.