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Recombinant Human sCD23 (FCER2)
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|Alternative Names||Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, B cell differentiation antigen
Recombinant Human C-type Lectin Domain Family 4 Member J (FCER2)
|Description||CD23 is a calcium dependent transmembrane glycoprotein which is expressed in many cell types. The cytoplasmic region of the protein has two isoforms â€“ the 'a' isoform that participates in IgE-regulated endocytosis, and the 'b' isoform, which is involved in IgE-regulated phagocytosis. It has been found that there are at least four soluble forms of the CD23 protein (sCD23) all of which are produced by the activity of metallo/cysteine proteases. In addition to binding IgE, sCD23 have been shown to promote the activation and differentiation of B-cells and stimulate the release of pro-inflammatory cytokines from monocytes.|
|Molecular Weight||19.5 kDa|
|Endotoxin Level||<1.0 EU/μg of recombinant protein as determined by the LAL method.|
|Purity||>95% as determined by SDS-PAGE|
|Bioactivity||Measured by its ability to bind in a functional ELISA. Immobilized rhCD23 at 2 Âµg/mL (100 ÂµL/well) can bind human IgE with a linear range of 0.015Â1 Âµg/mL.|
|Formulation||Lyophilized from a 0.2 Î¼m filtered solution in PBS|
|Reconstitution||Reconstitute at 100 Î¼g/mL in sterile PBS|
|Storage||The lyophilized protein is stable for at least one year from date of receipt at -70Â°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2Â° - 8Â°C for one month, or at -20Â°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.|
|Usage||For research use only. Not for diagnostic or therapeutic use.|
· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).
· For recombinant proteins: EU is reported per microgram of protein.
· One EU = 0.1-0.2 ng endotoxin/µg of protein.
· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.