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Recombinant Mouse MIP-3 (CCL19)


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Product Source Size Cat. No. Price
Recombinant Mouse MIP-3 (CCL19) E. coli20 µg Z200455 $70.00
1.0 mg Z200459 $1,750.00
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Data Sheet
Print Version
Alternative Names C-C motif chemokine 19, MIP3, Epstein-Barr virus-induced molecule 1 ligand chemokine, EBI1 ligand chemokine, ELC, Small-inducible cytokine A19
Description The chemokine MIP-3 beta is a chemoattractant for T and B lymphocytes, dendritic cells, macrophage progenitor cells, and natural killer cells. It might, therefore, play an important role in the trafficking of T cells in the thymus and migration of T and B cells to secondary lymphoid organs. Furthermore, MIP-3 beta has been recently shown to mediate rapid adhesion of naive CD4(+) T lymphocytes to activated endothelial cells supporting the role of this chemokine in regulation of lymphocyte homing. MIP-3 beta acts through CC chemokine receptor 7 (CCR7). The chemokines Lkn-1 and MIP-3 alpha are also lymphocyte attractants, although compared with MIP- 3 beta, their promigratory effect on lymphocytes is less intensive and their chemotactic activity is more promiscuous. Lkn-1 attracts monocytes, lymphocytes, and eosinophils via the chemokine receptors CCR1 and CCR3. MIP-3 alpha exhibits promigratory effects on lymphocytes, neutrophils, and immature dendritic cells via the CCR6 receptor.
Gene Symbol CCL19
Gene ID 24047
Accession No. O70460
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 10.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity Determined by its ability to chemoattract human dendritic cells using a concentration range of 10-50 ng/mL.
Formulation Recombinant CCL19 was lyophilized from a 0.2 μm filtered 20 mM PB,100 mM NaCl solution pH 7.5.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Product Documents
Product References
Submit a new question:
How are endotoxin levels measured?
1. For estimating the endotoxin levels; we use the LAL (Limulus Amebocyte Lysate) method: The lysate from horseshoe crab amebocytes clots in the presence of very low endotoxin. This reaction is the basis of the Limulus amebocyte lysate (LAL) assay which was approved by the FDA in 1970.

· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).

· For recombinant proteins: EU is reported per microgram of protein.

· One EU = 0.1-0.2 ng endotoxin/µg of protein.

· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.
With regard to the BSA levels in some Growth Factors and Cytokines, can you please provide an explanation as to why they are so high?
The amount of BSA, as part of the formulation of a protein, can vary considerably depending on how much BSA was deemed optimum/necessary for protein stability in combination with /in-lieu of - other possible additives. The aforementioned formulations are somewhat analogous to the “carrier” versions of many formulations from “R and D systems” that have as high as 50 µg of BSA per µg of the recombinant protein product. If, needed or desired, abm scientists can substitute BSA for other stabilizing additives for most formulations.
Are your Escherichia coli sourced growth factors: 1) Human derived materials free? 2) Recombinant proteins free?
Yes, all of abm's growth factors made in Escherichia coli using recombinant technology contain no human derived-products or other recombinant proteins. In the rare cases of BSA presence, this will be mentioned in the product's formulation.