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Recombinant Mouse SR-PSOX (CXCL16)

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Product Source Size Cat. No. Price
Recombinant Mouse SR-PSOX (CXCL16) E. coli25 µg Z200365 $70.00
1.0 mg Z200369 $1,890.00
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Data Sheet
Print Version
Alternative Names Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, C-X-C motif chemokine 16, Srpsox
Description CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. Membrane-bound CXCL16 is expressed by antigen-presenting cells such as monocytes, macrophages, B cells, and dendritic cells in the T cell zone of lymph nodes. Soluble CXCL16 can be generated by constitutive cleavage from the cell membrane and further enhanced by cell stimulation with phorbol esters. Soluble CXCL16 has been shown to induce chemotaxis of Th1, Tc1, and natural killer cells, which express the functional CXCR6 receptor. CXCL16 has also been reported as a novel angiogenic factor for human umbilical vein endothelial cells. Moreover, CXCL16 cDNA was shown to be identical to a novel scavenger receptor that binds phosphatidylserine and oxidized lipoprotein. Recently, expression of CXCL16 and/or CXCR6 was shown in nasopharyngeal carcinomas, gliomas, and rectal cancer. Through a cytokine antibody array, we reported that CXCL16 protein production was increased in aggressive prostate cancer cells compared with the less aggressive prostate cancer cells or benign prostate cells.
Gene Symbol CXCL16
Gene ID 66102
Accession No. Q8BSU2
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 20.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity Determined by its ability to chemoattract mouse lymphocytes using a concentration range of 2.0-40.0 ng/mL.
Formulation Lyophilized from a 0.2 μm filtered solution in PB and 100 mM NaCl pH 7.5.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Product Documents
Product References
FAQs
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How are endotoxin levels measured?
1. For estimating the endotoxin levels; we use the LAL (Limulus Amebocyte Lysate) method: The lysate from horseshoe crab amebocytes clots in the presence of very low endotoxin. This reaction is the basis of the Limulus amebocyte lysate (LAL) assay which was approved by the FDA in 1970.

· Endotoxin is generally measured in Endotoxin Units per milliliter (EU/mL).

· For recombinant proteins: EU is reported per microgram of protein.

· One EU = 0.1-0.2 ng endotoxin/µg of protein.

· At abm, we do the LAL chromogenic assays that can detect down to 0.01 EU/ml.
With regard to the BSA levels in some Growth Factors and Cytokines, can you please provide an explanation as to why they are so high?
The amount of BSA, as part of the formulation of a protein, can vary considerably depending on how much BSA was deemed optimum/necessary for protein stability in combination with /in-lieu of - other possible additives. The aforementioned formulations are somewhat analogous to the “carrier” versions of many formulations from “R and D systems” that have as high as 50 µg of BSA per µg of the recombinant protein product. If, needed or desired, abm scientists can substitute BSA for other stabilizing additives for most formulations.
Are your Escherichia coli sourced growth factors: 1) Human derived materials free? 2) Recombinant proteins free?
Yes, all of abm's growth factors made in Escherichia coli using recombinant technology contain no human derived-products or other recombinant proteins. In the rare cases of BSA presence, this will be mentioned in the product's formulation.