Anti-CD11a Antibody
| CAT.NO | UNIT | PRICE |
|---|---|---|
| Y059072 | 100 μg | $410.00 |
| Description | CD11a is non-covalently associated with β2-integrin; CD11a and β2-integrin form LFA-1. LFA-1 α chain is a unique epitope of LFA-1 implicated in activation of LFA-1 complex. |
|---|---|
| SKU | Y059072 |
| Unit quantity | 100 μg |
| Clone | Monoclonal |
| Raised in | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Specificity | The antibody reacts with α-subunit (CD11a) of human LFA-1, a 170-180 kDa type I transmembrane glycoprotein |
| Immunogen | Human peripheral blood lymphocytes |
| Applications | Functional Application: The antibody directly induces the binding of T cells to purified ICAM-1. Using an in vitro-translated CDlla cDNA deletion series, the antibody activation epitope was mapped to the "I" domain of the LFA-1 α subunit. The studies have therefore identified a novel LFA-1 activation epitope mapping to the I domain of LFA-1, which could play a role in the regulation of LFA-1 binding to ICAM-1. |
| Recommended Dilutions | Functional Application: The antibody directly induces the binding of T cells to purified ICAM-1. Using an in vitro-translated CDlla cDNA deletion series, the antibody activation epitope was mapped to the "I" domain of the LFA-1 α subunit. The studies have therefore identified a novel LFA-1 activation epitope mapping to the I domain of LFA-1, which could play a role in the regulation of LFA-1 binding to ICAM-1. |
| Formulation | Liquid |
| Concentration | 1ug/ul |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Guarantee | abm guarantees that all our Anti-CD11a Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Purity | Affinity purified |
Supporting Protocol
MSDS
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