Anti-Human p75NTR Antibody
|Description||p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3.|
|Unit quantity||50 μl|
|Species Reactivity||Human, Mouse, Rat, Other|
|Specificity||Specificity has been confirmed using a number of techniques as described in the reference by Rogers et al (2006).|
|Immunogen||Extracellular domain of human p75NTR|
|Applications||A concentration of 1-5 µg/ml is recommended for immunohistochemistry. A concentration of 20 µg/ml is recommended for immunofluorescence and FACS. The optimal working dilution should be determined by the end user.|
|Recommended Dilutions||A concentration of 1-5 µg/ml is recommended for immunohistochemistry. A concentration of 20 µg/ml is recommended for immunofluorescence and FACS. The optimal working dilution should be determined by the end user.|
|Storage Condition||This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.|
|Storage Buffer||PBS, pH 7.4 with 0.02% sodium azide.|
|Guarantee||abm guarantees that all our Anti-Human p75NTR Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.|
|Purity||Protein G Purified|
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