Anti-Mouse CD11b Antibody
|Description||The Anti-Mouse CD11b Antibody (M1/70) specifically binds to the mouse CD11b. CD11b (integrin αM glycoprotein) is a 170 kDa type 1 transmembrane glycoprotein which associates non-convalently with CD18 to form αMβ2 integrin (Mac-1) and binds to ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen, and heparin. CD11b (Mac-1) is expressed on the surface of myeloid-derived dendritic cells, tissue macrophages, NK cells, microglia, granulocytes, monocytes, and subsets of T and B cells (for instance, B-1 B lymphocytes). CD11b has been used as a marker to distinguish naive and memory CD8 T cells. It has been reported that M1/70 blocks cell adherence and C3bi binding. M1/70 is found to be cross-reactive to human CD11b expressed on human peripheral blood monocytes, granulocytes, and NK cells. This antibody is CyTOF® Label Ready and can be used directly for rare metal conjugation using MaxPar® metal labeling kits (Fluidigm). CyTOF® or mass cytometry uses rare metal conjugated antibodies to simultaneously profile over 40 different proteins on and within a single cell. CyTOF® antibodies have the advantage over the traditional flow cytometry for its minimal signal overlap and simplified high-dimensional panel design for simultaneously profiling the phenotype and function of all cells. Each lot of CyTOF® Label Ready antibody is guaranteed for its activity and high purity.|
|Species Reactivity||Human, Mouse, Other|
|Storage Condition||This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.|
|Storage Buffer||PBS, pH 7.4 with 0.05% sodium azide.|
|Guarantee||abm guarantees that all our Anti-Mouse CD11b Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.|
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