Anti-Myc (Ab-358) Antibody
|Description||The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]|
|Unit quantity||100 μg|
|Species Reactivity||Human, Mouse, Rat|
|Specificity||Myc (Ab-358) antibody detects endogenous levels of total Myc protein.|
|Immunogen||The antiserum was produced against synthesized non-phosphopeptide derived from human Myc around the phosphorylation site of threonine 358 (R-R-TP-H-N).|
|Applications||WB: 1:500~1:1000 IHC: 1:50~1:100|
|Recommended Dilutions||WB: 1:500~1:1000 IHC: 1:50~1:100|
|Storage Condition||This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.|
|Storage Buffer||phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Guarantee||abm guarantees that all our Anti-Myc (Ab-358) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.|
|Purity||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.|
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