dCas9 Synergistic Activation Mediator Lentivirus

Cat. No.
K016 - DISCONTINUED
Unit
4 x 500ul
Price
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Cat. No. K016 - DISCONTINUED
Name dCas9 Synergistic Activation Mediator Lentivirus
Unit 4 x 500ul
Description

This product has been replaced by CRISPRa dCas9-VPR Lentivirus (Cat. No. K098)

 

This Cas9 Double Mutant (dCas9) has changes at amino acid positions D10A and H840A which completely inactivate both the nuclease and nickase activities. With a target-specific guide RNA (sgRNA), it can bind to a specific region of DNA without cutting it. In this construct, dCas9 carries a C-terminal tripartite synergistic activation mediator (SAM). By targeting dCas9-SAM to a promoter region, users will be able to specifically induce expression of virtually any gene of interest.

Vector pLenti-EF1a-dCas9-SAM
Titer 107 IU/mL
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. K016 - DISCONTINUED
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  • Bayati, A et al. (2022). "Rapid macropinocytic transfer of α-synuclein to lysosomes." Cell Reports. 40(3):111102. DOI: 10.1016/j.celrep.2022.111102. Application: Organelle Labeling Lentivirus. 
  • Srinath S, Jishnu PV, Varghese VK, Shukla V, Adiga D, Mallya S, Chakrabarty S, Sharan K, Pandey D, Chatterjee A, Kabekkodu SP. Regulation and tumor-suppressive function of the miR-379/miR-656 (C14MC) cluster in cervical cancer. Mol Oncol. 2024 Feb 23. doi: 10.1002/1878-0261.13611. Epub ahead of print. PMID: 38400534.

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