Long non-coding RNAs (lncRNAs) are emerging as new players in the regulation of embryonic pluripotency, differentiation, patterning of the body axis and promoting developmental transitions. LncRNAs are transcribed RNA molecules greater than 200 nucleotides in length and are pervasively expressed across the genome. LncRNAs have been found to exhibit a wide range of functions in histone modification ranging from signaling, serving as molecular decoys, guiding ribonulceoprotein complexes to specific chromatin sites and also participating as scaffolds in the formation of complexes.

Endogenous antisense RNAs (asRNAs) have recently emerged as important regulators of gene expression working on a posttranscriptional level or influencing sense mRNA processing and may contribute to the physiological tuning of specific genes.

The function and activity of many lncRNAs and antisense RNAs still remain poorly understood. abm provides a variety of overexpression and knockdown tools for studying these molecules. Choose from pre-made adenovirus, adeno-associated virus (AAV) or lentivirus, as well as ORF and viral vectors to help further our understanding of the roles of lncRNAs and antisense RNAs in our genome. In addition to CMV and EF1a promoters, we also have the weaker UbC and PGK promoters available for cases where too high expression of lncRNAs or antisense RNAs may result in cell death.