Recombinant Human 4-1BB Receptor (TNFRSF9) (E. coli)
|Recombinant Human 4-1BB Receptor (TNFRSF9) (E. coli)
|4-1BB Receptor (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated natural killer cells. The binding of 4-1BB Receptor to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a co-stimulatory signal to resting T cells leading to high level IL2 production independently of CD28 signaling. Recombinant Human 4-1BB Receptor represents the soluble, cysteine-rich TNFR-like extracellular domain of 4-1BB Receptor.
|Human (H. sapiens)
Tumor necrosis factor receptor superfamily member 9, 41BB, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CD137
|Human (H. sapiens)
|< 1.0 EU/µg of recombinant protein as determined by the LAL method.
|>95% as determined by SDS-PAGE
|Lyophilized from 0.2 μm filtered solution in PBS (pH 7.5)
|The ED50 as determined by dose dependent proliferation of human megakaryocytic leukemia cell line is <0.5ng/ml.
|A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
|The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
|For research use only. Not for diagnostic or therapeutic use.
|If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101087
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