Recombinant Human ACK (N-GST tag)
|Description||ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs . Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality . Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC.|
|Aliases||TNK2, ACK1, FLJ44758, FLJ45547, p21cdc42Hs|
|Formulation||50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.|
|Molecular Weight||66.0 kDa|
|Species||Human (H. sapiens)|
|Usage||For research use only. Not for diagnostic or therapeutic use.|
|Storage||Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.|
|Unit quantity||10 µg|
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