Recombinant Human FLT3 Ligand (FLT3LG)

Cat. No.
Z100225
Unit
Price
$246.00
Cat. No. Z100225
Name Recombinant Human FLT3 Ligand (FLT3LG)
Description Known to bind to cells that express the tyrosine kinase receptor, FLT3LG promotes long-term expansion and differentiation of human pro-B cells. Human FLT3LG also stimulates the proliferation of cells expressing murine FLT-3 receptors. In combination with SCF and IL3, FLT3LG can cause expansion of cells with the marker spectrum CD34(+)/CD38(-). Alone, FLT3LG supports the survival of precursors in the lineage of blood-forming cells such as CFU-GM, CFU-GEMM, and the very primitive high proliferative potential colony-forming cells, HPP-CFC. FLT3LG has only marginal effects on progenitors for erythroid cells and megakaryocytes. Recombinant Human FLT3LG is a non-glycosylated, monomeric protein with intra-chain disulfide bonds.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family Other Growth Factors/Cytokines
Aliases Fms-related tyrosine kinase 3 ligand, FLT3 ligand, FLT3LG, FLT3L
Gene Symbol FLT3LG
Gene ID 2323
Accession Number P49771
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 17.8 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered PBS solution pH 7.0
Function The ED50 as determined by the dose-dependent stimulation of the proliferation of Human AML5 cells was found to be in the range of 1.0 ng/mL
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100225
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