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Colon Cancer Cell Collection

Powering Colorectal Cancer Research with Engineered and Translationally Relevant Models

86 human and mouse colon models for tumor biology, drug response, and immuno-oncology studies

March marks Colorectal Cancer Awareness Month. At Applied Biological Materials (abm), we support researchers with a diverse collection of colon cancer cell models for studying tumor biology, drug response, and immuno-oncology.

From validated human colorectal cancer lines to CRISPR-engineered systems and immuno-oncology models such as CT26 and MC38, these tools help accelerate pathway discovery, target validation, and screening workflows.

86Cell Models
5Research Applications
Human + MouseAvailable Models
CRISPREngineered Systems
Live CellReporter Models


Key Features for Colorectal Cancer Research

Our collection is built to support a broad range of colorectal cancer workflows, from foundational biology to translational studies and immunotherapy discovery.

Validated Models
Human Colorectal Cancer Cell Lines

Human colon cancer cell lines supporting translational research, mechanism studies, and therapeutic development.

CRISPR Tools
Cas9 and Knockout Systems

CRISPR-engineered and Cas9-ready models for studying gene function, signalling pathways, and treatment response.

Immuno-Oncology
CT26 and MC38 Models

Syngeneic and immune-relevant models for tumour–immune interaction studies, antigen evaluation, and checkpoint-related research.

Reporter Platforms
Real-Time Monitoring

Reporter and live-cell imaging models engineered to track gene activity, cell behaviour, and treatment response in real time.

Research Applications and Full Collection

Browse by application area or explore the full list of colon cancer and colon-derived cell models below.

Cat. No. Product Name Research Application
T6835 EMT Dual Reporter HCT116 Cell Line EMT / Metastasis
T6836 EMT Dual Reporter HT29 Cell Line EMT / Metastasis
T6837 EMT Dual Reporter SW620 Cell Line EMT / Metastasis
T6838 EMT Dual Reporter LS180 Cell Line EMT / Metastasis
T6839 EMT Dual Reporter SW480 Cell Line EMT / Metastasis
T0567 Immortalized Mouse Colonic Epithelial Cells - Conditionally (YAMC) General Cancer Research
T0570 Immortalized Human Colon Cells General Cancer Research
T3171 SIRT1 Wildtype Stable RKO Cell Line General Cancer Research
T3172 SIRT1 Knockout Stable RKO Cell Line General Cancer Research
T3173 SIRT1 Wildtype Stable DLD-1 Cell Line General Cancer Research
T3174 SIRT1 Knockout Stable DLD-1 Cell Line General Cancer Research
T3263 Cas9 Expressing HCT116 Cell Line General Cancer Research
T3363 Cas9 Expressing HCT-15 Cell Line General Cancer Research
T3389 Cas9 Expressing HT-29 Cell Line General Cancer Research
T3510 PINK1-YFP-IRES-DsRed Expressing HCT116 Stable Cell Line General Cancer Research
T3511 PINK1(F104M)-YFP-IRES-DsRed Expressing HCT116 Stable Cell Line General Cancer Research
T3905 GFP Stably Expressing HCT116 Cell Line General Cancer Research
T6028 SLC39A14 Stably Expressing Caco-2 Cell Line General Cancer Research
T6052 LoVo Control Cells (LoVo/vec) General Cancer Research
T6053 TIP49wt Stable Expressing LoVo Cell Line (LoVo/TIP49wt) General Cancer Research
T6054 TIP49D302N Stable Expressing LoVo Cell Line (LoVo/TIP49D302N) General Cancer Research
T6091 HIF-1α CRISPR Knockout CT26 Cell Line General Cancer Research
T6094 UCH37 CRISPR Knockout HCT116 Cell Line General Cancer Research
T6095 UCH37WT Expressing HCT116 Cell Line General Cancer Research
T6096 UCH37C88A Expressing HCT116 Cell Line General Cancer Research
T6097 UCH37EWI Expressing HCT116 Cell Line General Cancer Research
T6112 Stable CYP24A1 Expressing LS180 Cell Line General Cancer Research
T6113 Stable VDRE-I CYP24A1 Expressing LS180 Cell Line General Cancer Research
T6162 ADRM1 Stable Knockout HCT116 (Clone B11) Cell Line General Cancer Research
T6203 SPRY4-IT1 Stably Expressing Human HT-29 Cell Line General Cancer Research
T6349 IP6K1(-/-) Stable HCT116 Cell Line General Cancer Research
T6350 IP6K2(-/-) Stable HCT116 Cell Line General Cancer Research
T6351 IP6K1(-/-) & IP6K2(-/-) Stable HCT116 Cell Line General Cancer Research
T6409 GFP Stable MC-38 Cell Line General Cancer Research
T6444 CA-MEK5 Stably Expressing HCT116 Cell Line General Cancer Research
T6445 DN-MEK5 Stably Expressing HCT116 Cell Line General Cancer Research
T6452 MCM10 Exon 14 +/- Knockout Stable HCT116 Cell Line (Clone 8) General Cancer Research
T6453 MCM10 Exon 14 +/- Knockout Stable HCT116 Cell Line (Clone 14) General Cancer Research
T6518 CT26/NIS-ODC Cell Line General Cancer Research
T7813 GFP Expressing MC38 Stable Cell Line General Cancer Research
T8130 CCJ-25T4 Cell Line General Cancer Research
T8132 CCJ-52T Cell Line General Cancer Research
T8211 HT-29-Cl.27H Cells General Cancer Research
T8212 HT29-Cl.19A Cells General Cancer Research
T8213 HT29-Cl.16E Cells General Cancer Research
T8240 HCT116 Cells General Cancer Research
T8267 CT26 Cells General Cancer Research
T8291 MC-38 Cells General Cancer Research
T8354 HCT116/4008#13 rho-0 Cells General Cancer Research
T8972 HT-29 Cells General Cancer Research
T9150 CaCo-2 Cells General Cancer Research
T9543 NACC1 Stable Knockdown CT26 Cell Line #11 P3 General Cancer Research
T9563 ABCG2 CRISPR Knockout HT-29 Stable Cell Line-T1-8 General Cancer Research
T9611 CCL2 CRISPR Knockout CT26 Stable Cell Line General Cancer Research
T9636 Cas9 Expressing Mouse CT26 Cell Line General Cancer Research
T9719 Luciferase Stable Expressing MC38 Cell Line - Polyclonal General Cancer Research
T9779 GFP Expressing LOVO Stable Cell Line General Cancer Research
T9784 PIEZO1 CRISPR Knockout LOVO Stable Cell Line-T3-7 General Cancer Research
T9835 PIK3CA CRISPR Knockout HCT116 Stable Cell Line-T2-3 General Cancer Research
T3219 Apolipoprotein A-1 Expressing Stable MC38 Cell Line (MC38 Apo) Immuno-Oncology / Antigen Studies
T3220 Apolipoprotein A-1 and P144 Over-expressing Stable MC38 Cell Line (MC38 ApoLinkerP144) Immuno-Oncology / Antigen Studies
T6149 PD-L1 CRISPR Stable Knockout MC38 Cell Line Immuno-Oncology / Antigen Studies
T6237 PD-L1 CRISPR Stable Knockout CT26 Cell Line Immuno-Oncology / Antigen Studies
T6285 OPN Overexpressing HCT116 Cell Line Immuno-Oncology / Antigen Studies
T6286 OPN Overexpressing DLD1 Cell Line Immuno-Oncology / Antigen Studies
T6406 MUC1 Stable MC-38 Cell Line Immuno-Oncology / Antigen Studies
T6407 CEA-1 Stable MC-38 Cell Line Immuno-Oncology / Antigen Studies
T6408 CEA-2 Stable MC-38 Cell Line Immuno-Oncology / Antigen Studies
T9638 CD276 Stable Expressing CT26 Cell Line - Clone #25 Immuno-Oncology / Antigen Studies
T0715 Immortalized Human Colonic Epithelial Cells (HCEC-1CT) Normal / Rare Colon Lines
T1186 GP5d Cells Normal / Rare Colon Lines
T6011 Stable Smad4 Expressing SW480 Cell Line Normal / Rare Colon Lines
T6449 LSD1 Stable Knockdown SW480 Cell Line Normal / Rare Colon Lines
T7723 Scrambled (spCas9) Negative Control KRASG12D SW48 Stable Cell Line Normal / Rare Colon Lines
T8225 JVE-109 Cells Normal / Rare Colon Lines
T8236 HCT-8/VCR Cells Normal / Rare Colon Lines
T8418 SK-CO-1 Cells Normal / Rare Colon Lines
T9820 Human MPND CRISPR Knockout NCM460 Cell Line - T3-15 Normal / Rare Colon Lines
T9822 Scrambled (spCas9) Negative Control NCM460 Cell Line Normal / Rare Colon Lines
T9913 SW480 Cells Normal / Rare Colon Lines
T3283 hACE2-EGFP Stably Expressing DLD1 Cell Line Viral Infection / Immunology
T3408 hACE2 Stably Expressing Colon Cell Line (SW620.hACE2) Viral Infection / Immunology
T6582 IFNAR CRISPR Knockout MC38 Stable Cell Line - C8 Viral Infection / Immunology
T6583 IFNAR CRISPR Knockout MC38 Stable Cell Line - E9-T1 Viral Infection / Immunology
T8404 MC-38IFNAR WT Cells Viral Infection / Immunology
T9280 SARS-CoV-2 (2019-nCoV) Nucleoprotein / NP Stable Expressing Caco-2 Cell Line Viral Infection / Immunology

Additional Research Support

In further support of colorectal cancer researchers, abm also provides gene tools and cell engineering services to help discover new pathways, target validation, and screening workflows.

The abm Difference

More than a supplier, abm is your research partner — delivering trusted quality, rapid access, and expert support from project start to publication.

Ship-Ready Inventory

Our in-stock collection is prepared for fast fulfilment, helping you reduce downtime and move from planning to benchwork without unnecessary delays.

Scientist-to-Scientist Support

Our PhD-level team works with you directly to help identify the right model, recommend culture conditions, and support more complex study design questions.

Complete Documentation

Each order includes essential documentation such as CoA, passage history, culture guidance, and mycoplasma test reports for streamlined lab integration.

Trusted by Thousands

abm cell lines support work across oncology, pharmacology, and molecular biology, helping researchers generate reliable data backed by trusted materials.

Unlock abm-Crafted Colon Models

Browse the collection, request a quote, or contact our team for more information.