iPSC Characterization Kits
Induced Pluripotent Stem Cells, generally abbreviated as
iPS cells or iPSCs, are a type of pluripotent stem cell commonly derived from human somatic cells
through genetic modification and integration of specific DNA-transcription factors to reprogram
adult human cells to a pluripotent state. Literature suggests that Induced Pluripotent Stem Cells
and natural pluripotent stem cells, like embryonic stems cells, share identical qualities such as
the expression of certain stem cell genes and proteins, chromatin methylation patterns, doubling
time, embryoid body formation, teratoma formation, viable chimera formation, and potency and
differentiability. However, the full extent of their relation to natural pluripotent stem cells is
still being assessed.
Independent laboratories have established the fact that Sox2, c-myc, Lin28, KLF4,
and especially Oct4 and Nanog play essential roles in the induction of pluripotent stem cells.