» 


Edit, tag, silence, or activate any part of the genome with unprecedented specificity with our CRISPR toolkit. Empower yourself with CRISPR today and make the genome your playground!

Our Knockout Data Speaks for Itself

Right: ELISA measure of mouse LIF in cell-conditioned medium. Either wild type C26 mouse adenocarcinoma (C26) or CRISPR-derived mutants of these cells lacking the LIF gene (C26LIFKO cell line made by abm) were used to create conditioned medium. The wild type tumor cells secreted substantial levels of LIF into the medium while the knockout cells secreted undetectable or no LIF, an indication of correct CRISPR targeting in the cell line.

Data is courtesy of Dr. Robert Jackman (Boston University).

Cell Biology
Download CRISPR
Product Overview
Visit Our Knowledge Base
to Learn More About CRISPR

Hailed as the biggest biotech breakthrough of this decade, the simple and effective CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing system is revolutionizing how research is performed and even how diseases may be treated in the near future. As a leader in genetic engineering and viral vector technology, abm is constantly searching for and developing the most innovative and affordable technologies. That’s why we’re offering a comprehensive repertoire of CRISPR tools—from Cas9 nucleases, nickases, and double mutants, to sgRNA libraries and knockout cell lines that can target every human, mouse, and rat gene.

Videos

CRISPR Introduction

CRISPR - Methods and Tools

CRISPR - gRNA Design

Search By Gene Symbol or Accession Number



Selected Publications using our CRISPR Products

Kang, Y. J. et al. "Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling." Nat. Commun. (2015) 6:8371 doi: 10.1038/ncomms9371

Jiang, G. et al. "Isorhapontigenin (ISO) inhibits invasive bladder cancer (BC) formation in vivo and human BC invasion in vitro by targeting STAT1/FOXO1 Axis." Cancer Prev Res. Published Online First April 14, 2016. doi: 10.1158/1940-6207.CAPR-15-0338

Okugawa, Y. et al. "Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer." Gut (2015) doi:10.1136/gutjnl-2015-309359
Selected Testimonials of our CRISPR Products

"We are quite happy with the knockout cells that you made. This was a tricky knockout and hemizygous removal was much more prevalent than the double knockout, but you did it. In addition to your excellent genomic sequence characterization of both mutant LIF alleles, I have confirmed in our lab that the tumor cells have lost all mouse LIF production."
Dr. Robert Jackman, Boston University, Mouse LIF CRISPR Knock Out C26 Tumor Cell Line Generation and Screening Service

"We are very happy with the product and the turn around time, and would therefore order another reagent."
Dr. Alexandra Duverger, University of Alabama at Birmingham, CRISPR

"The All-in-One Lentivectors worked very well."
Dr. Makoto Miyazaki, University of Colorado-Denver, CRISPR

"Construct works beautifully, definitely will get more if needed."
Emily Chen, UCLA, CRISPR Lentivectors