CRISPR Genome Editing (Licensed)

abm, a leader in genetic engineering tool development for the last 15 years, holds a CRISPR license with ERS, co-founded by 2020 Nobel Prize winner Dr. Emmanuelle Charpentier, granting access to the ERS CRISPR/Cas9 patent portfolio.

This portfolio has more than 55 patents in the US covering the use of CRISPR/Cas9 gene editing in all cells, including eukaryotic. Companies based in the US, using CRISPR/Cas9 will require a CVC license.

Search CRISPR Gene Knockout Library

CRISPR Library
We offer genome-wide libraries of gene knockout sgRNAs for human, mouse, and rat genes in a full complement of viral and non-viral delivery systems, or ready-to-use CRISPR KO cell lines.

  • Introduction to CRISPR
    Introduction to CRISPR
    CRISPR Knowledge Base
  • CRISPR Methods and Tools
    CRISPR-Methods and Tools
    CRISPR Knowledge Base
  • sgRNA Design
    CRISPR-gRNA Design
    CRISPR Knowledge Base
  • CRISPR Gene Activation Repression
    CRISPR for Gene Activation and Repression
    CRISPR Knowledge Base
  • CRISPR Experimental Design Tool
    CRISPR Experiment Design Tool
    CRISPR Tools
  • CRISPR Knockout Manual
    CRISPR Knockout Manual
    CRISPR Guides/Manuals
  • CRISPR Case Studies
    CRISPR Case Studies
    CRISPR Guides/Manuals
  • CRISPR KO Results
    CRISPR KO Results
    Our data speaks for itself

Top Publications

Inferring and pertubing cell fate regulomes in human brain organoids.

Fleck, JS et al.
Nature. (2022)

doi: 10.1038/s41586-022-05279-8.

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Kang, Y. J. et al.
Nature Communications. (2015)

doi: 10.1038/ncomms9371

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.

Yamane, D. et al.
Nature Microbiology. (2019)

doi: 10.1038/s41564-019-0425-6


We are quite happy with the knockout cells that you made. This was a tricky knockout and hemizygous removal was much more prevalent than the double knockout, but you did it. In addition to your excellent genomic sequence characterization of both mutant LIF alleles, I have confirmed in our lab that the tumor cells have lost all mouse LIF production.

Dr. Robert Jackman
Boston University

Mouse LIF CRISPR Knock Out C26 Tumor Cell Line Generation and Screening Service

Construct works beautifully, definitely will get more if needed.

Emily Chen

CRISPR Lentivectors

The All-in-One Lentivectors worked very well.

Dr. Makoto Miyazaki
University of Colorado-Denver