dCas9-DNMT3A Lentivirus

Cat. No.
4 x 500ul
Cat. No. K092
Name dCas9-DNMT3A Lentivirus
Unit 4 x 500ul

This construct consists of the catalytic domain of DNA methyltransferase (DNMT3A) fused to the C-terminus of Cas9 Double Mutant (dCas9). The Cas9 Double Mutant has changes at amino acid positions D10A and H840A which completely inactivate both nuclease and nickase activities. The DNMT3A domain facilitates CpG site methylation leading to transcriptional down-regulation. By using specific sgRNAs, the dCas9-DNMT3A can be targeted to a promoter region allowing for epigenetic control over the expression of almost any gene of interest.

Vector pLenti-EF1a-dCas9-DNMT3A
Titer 107 IU/mL
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. K092
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  • Bayati, A et al. (2022). "Rapid macropinocytic transfer of α-synuclein to lysosomes." Cell Reports. 40(3):111102. DOI: 10.1016/j.celrep.2022.111102. Application: Organelle Labeling Lentivirus. 
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