circRNA tools for expression, enrichment, and study design
Circular RNA (circRNA) is studied for its covalently closed structure, improved stability relative to linear RNA, and relevance in functional and therapeutic research.
abm provides circRNA expression vectors, custom design services, enrichment tools, and supporting resources for circRNA workflows.
At a glance
- 1000+ circRNA over-expressing non-viral and AAV vectors
- Custom circRNA synthesis and cloning services
- RNase R and circRNA isolation tools for enrichment workflows
- Supporting data, publications, and resource content
circRNA in research
circRNA research spans expression, enrichment, and downstream biological interpretation across a range of experimental settings.
Why circRNA is studied
circRNA is studied to understand how circular transcripts affect expression and downstream biological function.
Fields of application
circRNA research supports multiple application areas across discovery and translational workflows.
Workflow overview
abm supports two circRNA research workflows depending on your starting material and experimental goal.
circRNA overexpression workflow
Start with circRNA expression vectors or custom construct design, followed by delivery and downstream expression or functional analysis.
circRNA isolation and enrichment workflow
Start from total RNA and use RNase R, isolation kits, and related tools to enrich circRNA for downstream analysis.
abm circRNA tools
Tools supporting circRNA overexpression workflows and circRNA isolation/enrichment workflows.
circRNA expression portfolio
Browse abm’s circRNA over-expressing non-viral and AAV vectors associated with human disease.
Custom circRNA vectors
Develop a custom circRNA construct through abm’s synthesis and cloning service in non-viral or AAV formats.
circRNA enrichment and sample preparation tools
Explore abm products supporting circRNA enrichment workflows, including RNase digestion, inhibition, and RNA preparation.
| Cat. No. | Product | Unit | Price |
|---|---|---|---|
| E049 | RNase R | 500 U (50 μl) | Inquiry |
| E049-G138S | RNase R + RNaseOFF Bundle | Bundle | Inquiry |
| G138 | RNaseOFF Ribonuclease Inhibitor | 4,000 U (100 µl) | Inquiry |
| G591 | RNaseOFF Ribonuclease Inhibitor | 100,000 U (2 x 1.25 ml) | Inquiry |
| G4001 | circRNA Isolation Kit | 25 Reactions | Inquiry |
| E099 | Poly(A) Polymerase (E. coli) | 25 U (25 µl) | Inquiry |
| G971 | RNA Purification Magnetic Beads | 5 mL | Inquiry |
Top publications
Selected references highlighting the relevance and expanding use of circRNA in research.
RNA circularization diminishes immunogenicity and can extend translation duration in vivo.
Molecular Cell. (2019)
Circ_0001103 alleviates IL-1β-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.
Clinical Immunology (2021)
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis.
Drug Delivery (2022)
Supporting resources
Additional resources for data, methods, and circRNA reference content.
circRNA supporting data
Review tested over-expression examples and workflow-related reference material.
circRNA educational content
Explore articles on circRNA introduction, expression methods, and enrichment, detection, and analysis.
Browse circRNA vectors
Explore abm’s circRNA vector catalogue, including non-viral and AAV options across disease-relevant targets.
Need help choosing a circRNA starting point?
Connect with abm for guidance on vector selection, custom design, or enrichment planning.