circRNA Research

abm is the leader in circRNA research and product development. This emerging technology has garnered abm a niche spotlight with circRNA researchers around the world. Our comprehensive product line offers circRNA over-expression vectors, purification kits and enzymes including our unique RNase R enzyme. 
 
circRNAs can be over-expressed in mammalian cells by using non-repetitive regions of reverse complementary sequences - these work to bring the exon-flanking portion of introns in close proximity, thus promoting back-splicing into circRNA. abm offers a collection of over 1000 circRNA over-expressing vectors. These circRNAs have been associated with human disease and can be used in over-expression studies to investigate new roles of circRNA in health.

Search circRNA Disease Expression Vector Library

circRNA Vector Library
We offer a large collection of disease-linked circRNA vectors which are ideal for over-expression studies.

Resources

  • Introduction to CRISPR
    Quantitative PCR (qPCR)
    PCR Learning Resources
  • CRISPR Methods and Tools
    Reverse Transcription
    PCR Learning Resources
  • sgRNA Design
    Introduction to NGS
    NGS Learning Resources
  • CRISPR Gene Activation Repression
    circRNA Expression Results
    Supporting Data

Top Publications

RNA circularization diminishes immunogenicity and can extend translation duration in vivo.

Wesselhoeft RA et al.
Molecular Cell. (2019)


doi:  10.1016/j.molcel.2019.02.015

Circ_0001103 alleviates IL-1β-induced chrondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.


Zhang M. et al.
Clinical Immunology (2021)


doi: 10.1016/j.clim.2021.108718

Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis. 

Xie H. et al.
Drug Delivery (2022)


doi: 10.1080/10717544.2022.2057617