CRISPR & Cas9 Proteins

CRISPR is the most versatile technology for genome editing and abm offers the largest selection of Cas9 proteins for CRISPR experiments. Cas9 Ribonucleoproteins (RNPs) are Cas9 proteins in complex with in vitro transcribed sgRNA. These RNPs can be used for in vitro pre-screening sgRNA candidates and can be directly transfected or electroporated into cells to achieve gene editing. 

Advantages of Cas9 RNP Delivery Method:

• No transcription or translation required, thus editing is rapid and transient
• No plasmid or virus is used, therefore no risk of genome integration of Cas9/sgRNA machinery
• Proteins are compatible with a wide range of organisms, no need to consider promoters & codon optimization

Additionally, abm is continually developing a range of CRISPR-Cas proteins, including popular variants like Cas12a, Cas12b, Cas13a, and Cas13b, while also advancing high-fidelity options for precise genetic editing. Visit our knowledge base for more information about CRISPR-related technology.