AAV Gene Expression Collection
As a leader in Adeno-Associated Virus (AAV) technology, abm offers an affordable, comprehensive collection of human, mouse and rat genes cloned into ready-to-use AAV vectors or packaged AAV virus (serotypes 1-11) for gene over-expression studies within a wide range of host cells. Our standard AAV Collection constructs are available with CMV or hSYN promoters with the option of a GFP reporter. Simply input your gene of interest into the search bar below.
Can't find the AAV construct you're looking for? Design your own vector using our Plasmid Planner.
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Advantages of the AAV System:
- Used as a promising candidate for gene therapy
- Does not elicit significant immune responses in vivo
- Broad tropism - tissue specificity with different AAV serotypes
- No integration into the host genome
- Ability to transduce both proliferating and quiescent cells
- Long-term expression in non-dividing cells
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Search AAV Collection
We offer over 40,000 human, mouse and rat genes available in AAV vector or virus format with a wide choice of promoters, reporters, and serotypes.
|01||Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.
Zhang, Y et al.
Nature 548(7665):52-57 (2017).
DOI: 10.1038/nature23282. PubMed: 28746310.
|02||Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Li, J., et al
J Mol Cell Cardiol. 115:170-178 (2018).
|What are the correct concentration units for each recombinant viral particle?|
For lentiviruses and retroviruses, they are measured in CFU/ml (colony-forming units per millilitre). Transduction with lentiviruses and retroviruses can cause the formation of colonies, which can be quantified for concentration. For AAV the titer is measured as genome copies per mL (GC/mL). Adenoviruses are measured as PFU/ml (plaque-forming units per millilitre). Transduction with adenoviruses will kill packaging cells, forming plaques in the process for quantification. The concentration for all three types of viruses can also be classified as IU/ml (Infectious Units/ml). Ultimately, the units refers to the viral particles and different units reflect the different assays involved.
|What is the solution that the packaging mix is provided in?|