siRNA Technology

siRNAs are powerful tools for gene silencing and can be delivered to the target cell or host via a variety of methods including ready-to-use lentivirus, AAV, adenovirus, or direct transfection of DNA plasmids or double stranded RNA (dsRNA). Our unique convergent dual promoter system avoids the need to design hair-pin loop shRNA structures, streamlining cloning and knockdown of the target gene.

We offer a comprehensive collection of human, mouse, and rat siRNAs pre-designed for knockdown of your gene of interest. Can't find what you're looking for? We can generate Custom siRNA vectors and viruses tailored to your experiment.

"The lentivirus (Cat. No. iV059988a) I received is working really well with my primary bone marrow stem cells. The transfection rate is nearly 70% in five days. Great product, I would like to continue to using your products.”

Wei Guo, University of Maryland, Ccl4 siRNA  Lentivirus (Rat), Cat. No. iv059988a

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siRNA Collection

We offer genome-wide libraries of siRNA for human, mouse, and rat in a full complement of viral and non-viral delivery systems.

Products

Lentivirus siRNA Expression Tools

AAV siRNA Expression Tools

Related Products

Services

Resources

Viral Expression Systems Brochure
Introductory Guide
piLenti-siRNA-GFP vector map

Vector Map
Lenti-siRNA Expression Systems Manual

Click to Download

Publications

01	Hindbrain insulin controls feeding behaviour Eerola K. et al. Molecular Metabolism (2022). DOI: 10.1016/j.molmet.2022.101614. Pubmed: 36244663

02	FSH blockade improves cognition in mice with Alzheimer's disease. Xiong J., et al. Nature (2022). DOI: 10.1038/s41586-0225-04463-0. Pubmed: PMC9940301.

03	HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution. Kuo FC., et al. Cell Reports (2022). DIO: 10.1016/j.celrep.2022.111136. Pubmed: PMC10073411.