CCND1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CCND1-specific vectors and viral particles designed for reliable CCND1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CCND1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CCND1 Gene Overview
| Gene Name | cyclin D1 |
|---|---|
| Gene Symbol | CCND1 |
| Synonyms | BCL1,PRAD1,U21B31,D11S287E |
| NCBI ID | 595 |
| Ensembl ID | ENSG00000110092 |
| Uniprot ID | P24385 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
Human CCND1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115390 | View Product |
| AAV Vector & Virus | Long-term expression | VC115390 | View Product |
| Adenovirus | Transient expression | A115390 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115390 | View Product |
| Gene knockout (non-viral) | PG115390 | View Product | |
| Gene knockout (AAV) | VG115390 | View Product | |
| CRISPR Activation | Gene activation | LA115390 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115390 | View Product |
| Gene knockdown (AAV) | VS115390 | View Product | |
| ORF Vector | Template DNA | PC115390 | View Product |
Mouse Ccnd1 Gene Overview
| Gene Name | cyclin D1 |
|---|---|
| Gene Symbol | Ccnd1 |
| Synonyms | cD1,CycD1,Cyl-1,PRAD1,bcl-1 |
| NCBI ID | 12443 |
| Ensembl ID | ENSMUSG00000070348 |
| Uniprot ID | P25322 |
| Gene Type | Protein coding |
Gene Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase activity; and protein kinase binding activity. Involved in negative regulation of epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; liver regeneration; and mammary gland development. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin D1-CDK4 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ccnd1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415390 | View Product |
| AAV Vector & Virus | Long-term expression | VC415390 | View Product |
| Adenovirus | Transient expression | A415390 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415390 | View Product |
| Gene knockout (non-viral) | PG415390 | View Product | |
| Gene knockout (AAV) | VG415390 | View Product | |
| CRISPR Activation | Gene activation | LA415390 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415390 | View Product |
| Gene knockdown (AAV) | VS415390 | View Product | |
| ORF Vector | Template DNA | PC415390 | View Product |
Rat Ccnd1 Gene Overview
| Gene Name | cyclin D1 |
|---|---|
| Gene Symbol | Ccnd1 |
| Synonyms | |
| NCBI ID | 58919 |
| Ensembl ID | ENSRNOG00000020918 |
| Uniprot ID | P39948 |
| Gene Type | Protein coding |
Gene Summary
Enables protein kinase binding activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and response to vitamin E. Predicted to be located in bicellular tight junction and nucleoplasm. Predicted to be part of cyclin D1-CDK4 complex; cyclin D1-CDK6 complex; and transcription repressor complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of atherosclerosis; impotence; interstitial cystitis; liver cancer; and transitional cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ccnd1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615390 | View Product |
| AAV Vector & Virus | Long-term expression | VC615390 | View Product |
| Adenovirus | Transient expression | A615390 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615390 | View Product |
| Gene knockout (non-viral) | PG615390 | View Product | |
| Gene knockout (AAV) | VG615390 | View Product | |
| CRISPR Activation | Gene activation | LA615390 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615390 | View Product |
| Gene knockdown (AAV) | VS615390 | View Product | |
| ORF Vector | Template DNA | PC615390 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |