CRISPR Activation Library
CRISPR Activation (CRISPRa) allows you to selectively activate any gene by up to multiple thousand-fold. The key to CRISPRa is the dCas9-SAM complex, consisting of a catalytically-inactive Cas9 fused to a Synergistic Activation Mediator. The dCas9-SAM system can be targeted to the promoter of your gene of interest by expressing it in combination with specially-designed CRISPR Activation sgRNAs.
abm offers a complete collection of sgRNA-expressing CRISPR activation plasmids and viruses designed specifically for CRISPR Activation of any human, mouse, or rat gene. Our CRISPRa sgRNAs are available in lentivector or pre-packaged lentivirus for your convenience. Pair with our dCas9-SAM lentivector or dCas9-SAM lentivirus for the perfect CRISPR Activation experiment!
Key Features
- Lentiviral delivery for integration of genetic material into host cells, leading to long term sgRNA expression.
- Lentiviral vectors can be transfected for non-integrating, transient sgRNA expression.
- A set of three sgRNA vectors/viruses is available for added assurance of efficient gene activation.
Looking for sgRNAs for other purposes (gene repression, epigenetic modification, etc.)? See our Custom CRISPR AAV Vectors and Viruses.
Search Activation Library
Activation Library
We offer sgRNA lentiviruses for activation of any human, mouse, or rat gene.
Can’t find what you’re looking for? Request a custom CRISPR sgRNA virus or vector with [email protected].
Product Information
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Vector Map
sgRNA for activation of your gene of interest is available in lentiviral vector or lentivirus format. -
Workflow
How to use abm's activation sgRNA lentiviruses in your CRISPR activation experiment. -
Need Help Getting Started?
Read our CRISPR Activation and Repression Knowledge Base article for more information.
Documents
Top Publications
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.
Kang, Y J et al.
Nat. Commun. 6:8371 (2015).
DOI: 10.1038/ncomms9371.
Isorhapontigenin (ISO) inhibits invasive bladder cancer (BC) formation in vivo and human BC invasion in vitro by targeting STAT1/FOXO1 Axis.
Jiang, G. et al.
Cancer Prev Res. Published Online First April 14, 2016.
doi: 10.1158/1940-6207.CAPR-15-0338
Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.
Okugawa, Y et al.
Gut (2015)
doi:10.1136/gutjnl-2015-309359
Browse Products
- Sku: 1000112
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610007C21Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610007C21Rik gene in CRISPRa applications.
- Sku: 1000212
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610007L01Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610007L01Rik gene in CRISPRa applications.
- Sku: 1000312
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610007P08Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610007P08Rik gene in CRISPRa applications.
- Sku: 1000412
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610007P14Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610007P14Rik gene in CRISPRa applications.
- Sku: 1000512
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610007P22Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610007P22Rik gene in CRISPRa applications.
- Sku: 1000612
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610009B22Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610009B22Rik gene in CRISPRa applications.
- Sku: 1000712
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610009D07Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610009D07Rik gene in CRISPRa applications.
- Sku: 1000812
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610009O20Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610009O20Rik gene in CRISPRa applications.
- Sku: 1000912
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610010B08Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610010B08Rik gene in CRISPRa applications.
- Sku: 1001012
Price: $95.00~$495.00
Unit: 1.0 μg per target, 300 μlThis CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the 0610010F05Rik gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the 0610010F05Rik gene in CRISPRa applications.