CRISPR Activation Library

CRISPR Activation (CRISPRa) allows you to selectively activate any gene by up to multiple thousand-fold. The key to CRISPRa is the dCas9-SAM complex, consisting of a catalytically-inactive Cas9 fused to a Synergistic Activation Mediator. The dCas9-SAM system can be targeted to the promoter of your gene of interest by expressing it in combination with specially-designed CRISPR Activation sgRNAs.

abm offers a complete collection of sgRNA-expressing CRISPR activation plasmids and viruses designed specifically for CRISPR Activation of any human, mouse, or rat gene. Our CRISPRa sgRNAs are available in lentivector or pre-packaged lentivirus for your convenience. Pair with our dCas9-SAM lentivector or dCas9-SAM lentivirus for the perfect CRISPR Activation experiment!

Key Features

  • Lentiviral delivery for integration of genetic material into host cells, leading to long term sgRNA expression.
  • Lentiviral vectors can be transfected for non-integrating, transient sgRNA expression.
  • A set of three sgRNA vectors/viruses is available for added assurance of efficient gene activation.

Looking for sgRNAs for other purposes (gene repression, epigenetic modification, etc.)? See our Custom CRISPR AAV Vectors and Viruses.

Search Activation Library

Activation Library

We offer sgRNA lentiviruses for activation of any human, mouse, or rat gene.



Product Information

  • pLenti-U6-sgRNA-PGK-Neo vector map
    Vector Map
    sgRNA for activation of your gene of interest is available in lentiviral vector or lentivirus format.
  • CRISPR dCas9 SAM Lentivector Lentivirus Workflow
    Workflow
    How to use abm's activation sgRNA lentiviruses in your CRISPR activation experiment.
  • CRISPR Activation and Repression Knowledge Base
    Need Help Getting Started?
    Read our CRISPR Activation and Repression Knowledge Base article for more information.

Top Publications

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Kang, Y J et al.
Nat. Commun. 6:8371 (2015).


DOI: 10.1038/ncomms9371.

Isorhapontigenin (ISO) inhibits invasive bladder cancer (BC) formation in vivo and human BC invasion in vitro by targeting STAT1/FOXO1 Axis.

Jiang, G. et al.
Cancer Prev Res. Published Online First April 14, 2016.


doi: 10.1158/1940-6207.CAPR-15-0338

Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

Okugawa, Y et al.
Gut (2015)


doi:10.1136/gutjnl-2015-309359

Browse Products

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  1. Sku: 6922712
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZWS1 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZWS1 gene in CRISPRa applications.


  2. Sku: 6922612
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZWINTAS gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZWINTAS gene in CRISPRa applications.


  3. Sku: 6922212
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZSCAN12L1 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZSCAN12L1 gene in CRISPRa applications.


  4. Sku: 6921012
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF864P gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF864P gene in CRISPRa applications.


  5. Sku: 6920912
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF850P gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF850P gene in CRISPRa applications.


  6. Sku: 6920812
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF838 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF838 gene in CRISPRa applications.


  7. Sku: 6920712
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF834 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF834 gene in CRISPRa applications.


  8. Sku: 6920612
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF833 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF833 gene in CRISPRa applications.


  9. Sku: 6920512
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF828 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF828 gene in CRISPRa applications.


  10. Sku: 6920412
    Price: $95.00~$495.00
    Unit: 1.0 μg per target, 300 μl
    This CRISPR activation and repression sgRNA lentivector/lentivirus is designed to activate the ZNF826 gene when paired with dCas9-SAM. sgRNAs are specially designed for use with the ZNF826 gene in CRISPRa applications.

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