CRISPR Gene Knockout AAV Library

abm's CRISPR Gene Knockout sgRNA AAV Vectors and Viruses have a broad host range and low immunogenicity - ideal for in vivo CRISPR experiments as they do not integrate into the host genome. spCas9 or saCas9 functions to create double-stranded breaks within an early exon triggering repair via Non-Homologous End Joining (NHEJ) mechanism resulting in deleterious frameshift mutations. We offer a comprehensive collection of All-in-One and sgRNA only expressing AAV constructs targeting any human, mouse or rat gene. Simply input your target gene or accession number into the search bar below. 

Key Features

  • Comprehensive collection of gene knockout sgRNAs 
  • Targets include all coding human, mouse and rat genes
  • Available in All-in-One (with saCas9) or sgRNA only constructs 
  • Available in a set of 3 sgRNA vectors/viruses for added assurance of successful gene knockout
  • Available AAV serotypes 1 to 11 for high transduction efficiency in specific tissues
  • AAV delivery for low immunogenicity and non-integrating expression of sgRNA and/or saCas9

Looking for constructs expressing multiple sgRNAs? Check out our Custom Multiplex sgRNA Service.

Search Gene Knockout sgRNA AAV Library

Knockout sgRNA AAV Library

We offer All-in-One and sgRNA only AAV vector/viruses for knockout of any human, mouse, or rat gene.

Additional Information

  • CRISPR Knockout Case Study
    Click to see our CRISPR Knockout Case Study, including experimental design and supporting data.
  • CRISPR AAV Workflow
    How to use abm's sgRNA AAVs in your CRISPR knockout experiment.
  • CRISPR Knockout Guide
    Need Help Getting Started?
    This handbook outlines guidelines for CRISPR sgRNA design and the experimental procedures needed to achieve a specific gene knockout.

Top Publications

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Kang, Y J et al.
Nat. Commun. 6:8371 (2015).

DOI: 10.1038/ncomms9371.

Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.

Shirasaki, T. et al.
Nature Communications. (2022).

doi: 10.1038/s41467-022-30879-3

Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

Okugawa, Y et al.
Gut (2015)