One of the major goals of iPSC research is for disease modeling and novel therapeutic (clinical) applications. To simplify iPSC induction, scientists at abm have successfully developed a broad line of iPSC reprogramming factors including proteins, lysates, lentiviruses, adenoviruses, minicircle DNA and cord blood episomal iPSC vectors.
Scientists at abm Inc. provide researchers with the most comprehensive reprogramming vectors for iPSC research. Every vector has been sequenced and rigorously tested to ensure functionality. With those tools readily available, research scientists can now focus on their research projects without having to spend time on the development of basic vectors of their own. Preliminary customer feedback has shown that the episomal plasmids we designed and lentivirus we produced are also significantly more efficient in reprogramming fibroblasts from mice, rats and humans than other similar vectors on the market.
- Human and mouse recombinant iPSC proteins in either crude cell lysate or purified protein format completely eliminates genome manipulation associated with vector-based iPSC factors.
- Comprehensive selection of iPSC lentiviral vectors and viruses with choice of different promoters, plus a polycistronic iPSC lentivector or lentivirus containing all four transcription factors in the Thomson (OSNL) Protocol.
- Adenovirus formats for highly efficient, non-integrating transient transduction in most cell lines, based on human adenovirus type 5 and prepared in high titer format for immediate applications.
- Minicircle DNA, available with either a CMV or EF1α promoter and a GFP reporter for transgene expression, is the only truly xeno-free plasmid without any sequence of bacterial or viral origin and is ideal for xeno-free iPSC reprogramming.
- Using oriP/EBNA1 (Epstein-Barr nuclear antigen-1)-based episomal vectors have been shown to be effective in the reprogramming of human cord blood cells (CB) or peripheral blood (PB) cells, presenting great potential applications in future regenerative medicine due to its easy accessibility as compared to isolation of same type of cells from bone marrow.
- Licensed from the University of Toronto, highly sensitive and universally applicable EOS lentiviral and adenoviral vectors are available for immediate iPSC identification. The EOS (Early Transposon promoter and Oct-4 and Sox2 enhancers) element is a newly identified promoter that is only functional in stem cells, not differentiated cells, and is thus useful as a reporter promoter for stem cell identification.
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- Sku: G323
Unit: 200 μlLenti-III-CMV Virus expressing human KLF4 cDNA.
- Sku: G324
Unit: 200 μlLenti-III-CMV Virus expressing human Lin28 cDNA.
- Sku: G339
Unit: 200 μlLenti-III-CMV Virus expressing human Myc cDNA.
- Sku: G325
Unit: 200 μlLenti-III-CMV Virus expressing human Nanog cDNA.
- Sku: G326
Unit: 200 μlLenti-III-CMV Virus expressing human Oct4 cDNA.
- Sku: G340
Unit: 200 μlLenti-III-CMV Virus expressing human Sox2 cDNA.
- Sku: G353
Unit: 5 x 200 μlFive Lenti-III-CMV viruses, expressing the Thomson iPSC factor set (Oct4, Sox2, Nanog and Lin28) and a GFP control. Purified ready-to-use high titer lentivirus at 1x107 cfu/mL
- Sku: G415
Unit: 200 μl
- Sku: G369
Unit: 200 μlThe polycistronic lentivirus expresses all of the four mouse transcription factors (mOSNL of Thomson set: mOct4, mSox2, mNanog or mLin28) within a single expression cassette under the control of EF1α promoter. Each of the factor's ORF is separated...