Question (2318)
Question
What are the appropriate AAV serotypes for different cell types/tissues?
ABM community
Verified customer
Asked on Jan 16 2026
Answer
AAV serotypes have different tropisms (preferred target tissues/cell types), so selecting the right serotype can significantly improve transduction efficiency. In general:
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AAV9/AAVrh10: commonly used for CNS and systemic delivery (AAV9 can cross the BBB under some conditions)
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AAV8: strong performance in liver-directed expression
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AAV1/AAV6: commonly used for muscle and some lung/immune-related applications
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AAV2: widely used, especially for CNS/retina, but performance depends heavily on cell type and receptor availability
Because transduction efficiency can vary by model system, promoter, dose, and delivery route, we recommend customers consult publications using the same target cell type/tissue and testing more than one serotype when possible.
ABM Scientific Support
Answered on Jan 16 2026