TO1-3PEG-Biotin Fluorophore

CAT.NOUNITPRICE
G9550.5 mg/ml (500 µl)
$195.00

Specifications


DescriptionRNA Mango technology is based on the specific binding of the RNA Mango Aptamer and a Thizole Orange (TO) bi-functional dye. The main features of this technology is the tight binding between the dye and aptamer (KD ≈ 3nM) , and the strong ~1000X enhancement of the dye’s fluorescence when bound to the Mango apatmer (Fluorescent enhancement FE=1,100).
The TO dye has a number of other desirable properties including:
  • small size
  • lack of toxicity
  • plasma and nuclear membrane permeability
  • short intracellular half-life
  • the accessibility of a broad wavelength range simply via substitutions and alterations to the TO structure
TO1-biotin is the standard variety of TO dye for RNA Mango experiments; other dye variants will also be available soon.
SKUG955
Unit quantity0.5 mg/ml (500 µl)
Storage Condition

Stored at -20°C and protect from light.

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        References


        2
        • Abdolahzadeh, A., Dolgosheina, E. V., & Unrau, P. J. "RNA detection with high specificity and sensitivity using Nested Fluorogenic Mango NASBA" RNA rna-072629: (2019).
        • Cawte, A. D., Unrau, P. J., & Rueda, D. S. "Live Cell Imaging of Single RNA Molecules with Fluorogenic Mango II Arrays" bioRxiv. : (2019). DOI: 10.1101/840082.