Cas9 Nickase Lentiviral Vector

Cat. No.
K005
Unit
10 µg
Price
$212.00
Cat. No. K005
Name Cas9 Nickase Lentiviral Vector
Unit 10 µg
Description

This Cas9 nickase can be used with two target-specific sgRNAs to bind DNA and create two single-stranded cuts. Due to the requirement for two sgRNA guide sequences to be close together for gene editing to occur, using Cas9 nickase should cause fewer off-target effects than using Cas9 nuclease.

Vector pLenti-EF1a-Cas9-Nickase-SV40-Puro
Note

Cas9 Nickase includes N-terminal SV40 NLS

Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. K005
Print & Download Datasheet
  • The Board of Regents of the University of Texas System., . "GENERATION OF GENETICALLY ENGINEERED ANIMALS BY CRISPR/CAS9 GENOME EDITING IN SPERMATOGONIAL STEM CELLS" United States Patent Application 20190134227. Retrieved from : (2019).
  • Mohler, . "U" S. Patent Application No. 0201442 A1 : (2019).
  • Bayati, A et al. (2022). "Rapid macropinocytic transfer of α-synuclein to lysosomes." Cell Reports. 40(3):111102. DOI: 10.1016/j.celrep.2022.111102. Application: Organelle Labeling Lentivirus. 
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