hPSEN1(L435F) Stably Expressing MEF Psen1/2(-/-) Cell Line

CAT.NOUNITPRICE
T64431x106 cells / 1.0 ml
$0.00

Specifications


DescriptionMEF Psen1/2-/- cells were derived from E8.5 embryos which are neomycin and hygromycin-resistant and were immortalized with SV40 large T antigen via transfection with the pMSSVLT plasmid. Human PSEN1 D257A mutant expression was established through retroviral transduction with pMSCV puro hPSEN1WT plasmid with site directed mutagenesis and stable expression was determined via puromycin selection. PSEN1 (Presenilin 1) is a gene of interest in neuropathology and diseases such as Alzheimer's disease (AD) in which patients with an inherited form of the disease carry mutations. abm offers a panel of Stable MEF expressing human PSEN1 wildtype and various human PSEN1 mutants for research.
SKUT6443
SpeciesMouse (M. musculus)
Tissue/Organ/Organ SystemEmbryo
Cell MorphologyFibroblast-like
ApplicationsFor Research Use Only
Cell TypeDrug Discovery Cell Lines
Growth PropertiesAdherent
Expression ProfileHuman PSEN1L435F Neomycin (G418); hygromycin; and puromycin-resistant
Preservation Protocol1. Freeze Medium: Complete growth medium with 20% FBS and 10% DMSO.
2. Storage Temperature: Liquid nitrogen vapour phase.
Unit quantity1x106 cells / 1.0 ml
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Supporting Protocol
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