Recombinant Human GDNF (E. coli)

Cat. No.
Z101055
Unit
Price
$158.00
Cat. No. Z101055
Name Recombinant Human GDNF (E. coli)
Description GDNF is a disulfide-linked, homodimeric neurotrophic factor that belongs to the cystine-knot family of growth factors. Natively glycosylated, GDNF signals through a multi-component receptor system that comprises of a RET and one of the four GFRα receptors. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity Recombinant Human GDNF is a non-glycosylated, disulfide-linked homodimer (30 kDa) consisting of 135 amino acids in each subunit.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family TGF-beta Super-family
Aliases GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, ATF
Recombinant Human Glial-Derived Neurotrophic Factor (GDNF)
Gene Symbol GDNF
Accession Number P39905
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 15 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and NaCl (pH 4.0)
Function The ED50 as determined by the proliferation of rat C6 cells was found to be <0.1 ng/mL
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101055
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