SensiStain™ Anti-CMTM6 Antibody
| Cat. No. | HY000275 |
| Name | SensiStain™ Anti-CMTM6 Antibody |
| Clone | IHC700 |
| Category | IHC Antibodies |
| Gene Name | CMTM6 |
| Gene Full Name | CKLF-like MARVEL transmembrane domain containing 6 |
| Alias | FLJ20396 |
| Accession Number | BC002797 |
| Application | ELISA, IHC |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Human |
| Description |
CMTM6, also referred to as CKLF Like MARVEL Transmembrane Domain Containing 6, is widely expressed in many tissues, but the function relatively remains unknown. SensiStain™ Anti- CMTM6 Antibody detects the presence of CMTM6 which can be found binding to PD-L1 and maintains its cell surface expression. Studies have showed that due to the binding to PD-L1, CMTM6 co-localizes at plasma membrane and recycling endosomes preventing PD-L1 from being targeted for lysosome-mediated degradation. Due to the high specificity CMTM6 has with PD-L1, it can be studied alongside with PD-L1 as it has a role in suppression of tumour-specific T cell activity. |
| Immunogen | Recombinant Protein |
| Isotype | IgG1 |
| Uniprot Number | Q9NX76 |
| Recommended Dilutions |
1:50-1:200 |
| Storage Buffer | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Condition |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. HY000275 |
- Gao, F., Chen, J., Wang, J., Li, P., Wu, S., Wang, J., & Ji, Y. "CMTM6, the newly identified PD-L1 regulator, correlates with PD-L1 expression in lung cancers" Biochemistry and biophysics reports 20:100690 (2019).