Anti-Cas9 Antibody is an antibody against Cas9, an essential RNA-guided DNA endonuclease observed originally in Streptococcus pyogene among other bacteria and archaea and a component of an adaptive microbial immune system that provides acquired immunity against foreign viruses and plasmids. Cas9 endonuclease is used to cleave double-stranded DNA directed by a short engineered guide-RNA (gRNA), leading to site-directed double strand breaks (DSB) in DNA submstrate. Thus, the CRISPR Cas9 system (clustered regularly interspaced short palindromic repeat CRISPR-associated protein 9) is the latest RNA-guided, endonuclease tool in genome editing which allows for very specific genomic disruption and replacement.
|Unit quantity||100 μl|
|Immunogen||Recombinant fragment corresponding to Cas9 endonuclease from Streptococcus pyogenes.|
Working dilution must be determined by the user.
|Recommended Dilutions||Working dilution must be determined by the user.|
|Concentration||100 μg / 100 μl|
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
|Storage Buffer||PBS, pH 7.4 with 0.02% sodium azide.|
abm guarantees that all our Anti-Cas9 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
|Purity||Affinity purified from ascites fluid.|
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