Recombinant Human BCA-1 (CXCL13)

Cat. No.
Z100075
Unit
Price
$246.00
Cat. No. Z100075
Name Recombinant Human BCA-1 (CXCL13)
Description The homeostatic chemokine CXCL13 is constitutively expressed in secondary lymphoid tissue and known to initiate lymphoid neogenesis when expressed aberrantly in mice. CXCL13 has also been detected in chronic inflammation associated with human lymphoid neogenesis, suggesting a pathogenic role. Follicular dendritic cells are generally considered to be the major source of CXCL13 both in normal and aberrant lymphoid tissue. CXCL13 has been the exclusive ligand for CXCR5, which initiates chemotaxis toward an increasing gradient in vitro and to B cell zones in lymph nodes that express CXCL13. More recently, CXCR5 expression has also been shown in DN T cells in mice, a subset of CD4 follicular Th cells, and some tonsillar CD4+ and CD25+ Tregs in humans.
Organism Human (H. sapiens)
Unit quantity 20 µg
Family Chemokine-alpha Family (CXC)
Aliases BCA1, BLC, B cell Attracting Chemokine-1, CXCL13, C-X-C motif chemokine 13
Gene Symbol CXCL13
Gene ID 10563
Accession Number O43927
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 10 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 µm filtered solution in PBS,100 mM NaCl, pH 7.5
Function Determined by its ability to chemoattract human CXCR5 transfected mouse BaF3 B cells, the ED(50) is less than 20 ng/mL
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100075
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