Recombinant Human Cardiotrophin-1 (CT-1) (E. coli)

Cat. No.
Z102365
Unit
Price
$79.00
Cat. No. Z102365
Name Recombinant Human Cardiotrophin-1 (CT-1) (E. coli)
Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family IL-6 Family
Aliases Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1
Gene Symbol CTF1
Gene ID 1489
Accession Number Q16619
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 21 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 µm filtered solution in PBS
Function ED50 is ≤ 0.5 ng/mL as determined by the dose-dependent TF-1 cell proliferation.
Reconstitution Reconstitute in sterile 20mM Tris, pH 8.0 at 100µg/mL (containing at least 0.1% human or bovine serum albumin). Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1–1.0% BSA.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z102365
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