Recombinant Human CXCL12 (SDF-1 beta) (E. coli)

Cat. No.
Z101645
Unit
Price
$89.00
Cat. No. Z101645
Name Recombinant Human CXCL12 (SDF-1 beta) (E. coli)
Description A member of the CXC chemokine family, CXCL12 is strongly chemotactic for T-, B-, and cancer cells. Known to exert its effects mainly through binding to the CXCR4 receptor, CXCL12 plays an important role in morphogenesis, angiogenesis, and cancer metastasis. CXCL12 also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12. Encoded by a single gene, SDF-1 alpha (89 amino acids) and SDF-1 beta (93 amino acids) are derivatives of an alternative splicing event. SDF-1α and SDF-1β have identical amino acid sequences, differing only, by the presence of four extra amino acids at the C-terminus of the β form. SDF-1 beta is constitutively expressed by stromal cells.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family Chemokine-alpha Family (CXC)
Aliases Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, Pre-B cell growth-stimulating factor, PBSF
Recombinant Human Stromal Cell-Derived Factor-1 Beta (CXCL12)
Gene Symbol CXCL12
Gene ID 6387
Accession Number P48061
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 8.5 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in sodium phosphate and NaCl (pH 7.5)
Function Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 5.0-40 ng/mL
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101645
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