Recombinant Human FGF23

Cat. No.
Cat. No. Z100985
Name Recombinant Human FGF23
Description FGF-23 is a protein of ∼30 kDa that is proteolytically processed to generate smaller N-terminal (18 kDa) and C-terminal (12 kDa) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D
Organism Human (H. sapiens)
Unit quantity 20 µg
Family FGF Family
Aliases FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, HYPF
Recombinant Human Fibroblast Growth Factor 23 (FGF23)
Gene Symbol FGF23
Gene ID 8074
Accession Number Q9GZV9
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 23 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant Human FGF23 was lyophilized from 0.2 μm filtered PBS solution, pH 7.4.
Function The ED(50) was determined by the dose-dependent proliferation of mouse 3T3 cells expressing FGF receptors, and was found to be < 0.3 ug/mL, corresponding to a specific activity of 3.0 x 10^4 units/mg.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100985
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Controls and Related Product:

1.0 mg

50 µg

50 µg

10 µg