Recombinant Human Galectin-1 (LGALS1) (E. coli)

Cat. No.
Cat. No. Z101845
Name Recombinant Human Galectin-1 (LGALS1) (E. coli)
Description Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.
Organism Human (H. sapiens)
Unit quantity 15 µg
Family Other Growth Factors/Cytokines
Aliases Beta-Galactoside-Binding Lectin L-14-I, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1
Gene Symbol LGALS1
Gene ID 3956
Accession Number P09382
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 14.9 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in PBS and 2-ME with BSA as a carrier protein.
Function Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 0.5­3 µg/mL.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101845
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Controls and Related Product:

1.0 mg

50 µg

50 µg

10 µg