Recombinant Human GRO gamma (CXCL3) (E. coli)

Cat. No.
Z101465
Unit
Price
$89.00
Cat. No. Z101465
Name Recombinant Human GRO gamma (CXCL3) (E. coli)
Description Growth regulated oncogene-gamma belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity) and the new designation is CXCL3. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family Chemokine-alpha Family (CXC)
Aliases C-X-C motif chemokine 3, GRO-gamma(1-73), Growth-regulated protein gamma, GRO-gamma, Macrophage inflammatory protein 2-beta, MIP2-beta
Recombinant Human Growth Regulated Oncogene Gamma (CXCL3)
Gene Symbol CXCL3
Accession Number P19876
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 8 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant GRO-gamma/CXCL3 was lyophilized from a 0.2 μm filtered concentrated (1.0 mg/mL) solution in 40 mM NaCl, 10 mM PB, pH 7.0.
Function Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/mL.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101465
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