Recombinant Human IGFBP3 (E. coli)

Cat. No.
Z100375
Unit
Price
$284.00
Cat. No. Z100375
Name Recombinant Human IGFBP3 (E. coli)
Description IGFBPs are synthesized in the liver and are produced also by various tumor cell lines and cell types. IGFBPs are high affinity binding proteins for IGF. The major fraction of both types of IGF circulating in the blood are bound non- covalently to these carrier proteins. IGF binding proteins modulate IGF activities by increasing their plasma half lives and by inhibiting or promoting the interactions of IGF with receptors on certain target cells. In addition these binding proteins provide a reservoir for IGF in pericellular spaces. Some IGFBPs also have stimulating effects in vitro and some may inhibit the growth of cells. IGFBP1 is found predominantly in the placenta and the amniotic fluid. The predominant sites of IGFBP1 transcription in the human fetal kidney are those with most active differentiation. Elevated serum levels have been observed in patients with Laron-type dwarfism and Growth hormone deficiency. High serum levels of IGFBP1 are found in newborns and it has been suggested that this could be important in protecting them from hypoglycemia.
Organism Human (H. sapiens)
Unit quantity 25 µg
Family IGF/Insulin Family
Aliases IGF-binding protein 3, IGF-BP3, IBP-3
Recombinant Human Insulin-like Growth Factor Binding Protein 3 (IGFBP3)
Gene Symbol IGFBP3
Gene ID 3486
Accession Number P17936
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 28 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant IGFBP3 was lyophilized from a 0.2 μm filtered PBS solution.
Function The ED(50) was determined by the ability to inhibit IGF-I induced proliferation of MCF-7 and was found to be ≤ 0.5 μg/mL.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100375
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