Recombinant Human IL11 (E. coli)

Cat. No.
Z100425
Unit
Price
$89.00
Cat. No. Z100425
Name Recombinant Human IL11 (E. coli)
Description IL11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL11 receptor has been identified independently as Etl2. IL-1 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL11 promotes the proliferation of IL6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL11 also stimulates the T cell dependent development of IgG-secreting B cells in spleen cell cultures. IL11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family IL-6 Family
Aliases IL-11, Adipogenesis inhibitory factor, AGIF, INN=Oprelvekin
Recombinant Human Interleukin-11 (IL11)
Gene Symbol IL11
Gene ID 3589
Accession Number P20809
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 19 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in tris buffer and NaCl.
Function The ED(50) was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1.0 x 10^6 units/mg.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100425
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