Recombinant Human IL6 (E. coli)

Cat. No.
Z100555
Unit
Price
$246.00
Cat. No. Z100555
Name Recombinant Human IL6 (E. coli)
Description IL6 is a pleiotropic cytokine that participates in a wide variety of biological functions such as acute phase response, inflammation, hematopoiesis, bone metabolism and cancer. While produced mainly by stimulated monocytes, fibroblasts and endothelial cells, IL6 is also known to be produced by macrophages, T cells, B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells and keratinocytes, upon stimulation. Unlike murine IL6 which is inactive on human cells, both human and murine IL6 are equally active on murine cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids (designated CD126). Recombinant human IL6 is a 21 kDa, non-glycosylated protein that contains two disulfide bridges.
Organism Human (H. sapiens)
Unit quantity 20 µg
Family IL-6 Family
Aliases IL-6, B cell differentiation factor, BCDF, B cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, HPGF, HSF, MGI-2, Hybridoma growth factor, Interferon beta-2, IFN-beta 2
Recombinant Human Interleukin-6 (IL6)
Gene Symbol IL6
Gene ID 3569
Accession Number P05231
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 21 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.4)
Function The ED50 as determined by the dose-dependent stimulation of human TF-1 cells was in the range of 0.5-1 ng/mL
Reconstitution A quick spin of the vial followed by reconstitution in sterile PBS to a concentration not less than 0.1 mg/mL.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100555
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