Recombinant Human NTF4

Cat. No.
10 µg
Cat. No. Z100935
Name Recombinant Human NTF4
Description Neurotrophins are well-known retrograde signaling molecules that regulate differentiation and cell survival in many central and peripheral neurons. Neurotrophin-4 (NT-4) is the most recently discovered neurotrophic factor in mammals and, functionally, the least well understood. Little is known about the role of NT-4 in supporting the survival of identified classes of sensory neurons. Currently, the only available data are from cell counts of whole sensory ganglia. Mice lacking NT-4 (NT-4/) exhibit a loss of ~50% of the neurons in the nodose-petrosal and geniculate ganglia but no apparent loss of neurons in the dorsal root ganglia.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family Neuritin/NGF-β/NOTCH Families
Aliases NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF5, NTF4
Recombinant Human Neurotrophin-4 (NTF4)
Gene Symbol NTF4
Gene ID 4909
Accession Number P34130
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 14 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant NT-4 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
Function The ED(50) was determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures, and was found to be in a range of 10-50 ng/mL.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100935
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Controls and Related Product:

1.0 mg

50 µg

50 µg

10 µg