Recombinant Human PTH (E. coli)

Cat. No.
Z100775
Unit
Price
$89.00
Cat. No. Z100775
Name Recombinant Human PTH (E. coli)
Description Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.
Organism Human (H. sapiens)
Unit quantity 100 µg
Family Other Growth Factors/Cytokines
Aliases PTH, Parathormone, Parathyrin
Recombinant Human Parathyroid Hormone (PTH)
Gene Symbol PTH
Gene ID 5741
Accession Number P01270
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 9 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in PBS
Function The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Osteoblasts- SV40 and was found to be <0.5ng/mL.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100775
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